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  1. Article ; Online: In outpatients with COVID-19 during Omicron variant circulation, molnupiravir and nirmatrelvir-ritonavir improved outcomes.

    Chagla, Zain

    Annals of internal medicine

    2024  Volume 177, Issue 1, Page(s) JC7

    Abstract: Source citation: Sommer I, Ledinger D, Thaler K, et al. ...

    Abstract Source citation: Sommer I, Ledinger D, Thaler K, et al.
    MeSH term(s) Humans ; Antiviral Agents/therapeutic use ; COVID-19 ; COVID-19 Drug Treatment ; Cytidine/analogs & derivatives ; Hydroxylamines ; Lactams ; Leucine ; Nitriles ; Outpatients ; Proline ; Ritonavir/therapeutic use ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Cytidine (5CSZ8459RP) ; Hydroxylamines ; Lactams ; Leucine (GMW67QNF9C) ; molnupiravir (YA84KI1VEW) ; nirmatrelvir (7R9A5P7H32) ; Nitriles ; Proline (9DLQ4CIU6V) ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J23-0108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In patients with COVID-19, viral shedding time is 17 d and varies in some subgroups.

    Chagla, Zain

    Annals of internal medicine

    2021  Volume 174, Issue 8, Page(s) JC94

    Abstract: Source citation: Yan D, Zhang X, Chen C, et al. ...

    Abstract Source citation: Yan D, Zhang X, Chen C, et al.
    MeSH term(s) COVID-19 ; Humans ; Public Health ; SARS-CoV-2 ; Virus Shedding
    Language English
    Publishing date 2021-08-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202108170-094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In high-risk adults, the Moderna vaccine had 94% efficacy against COVID-19 ≥14 d after the 2nd dose.

    Chagla, Zain

    Annals of internal medicine

    2021  Volume 174, Issue 3, Page(s) JC28

    Abstract: Source citation: Baden LR, El Sahly HM, Essink B, et al. ...

    Abstract Source citation: Baden LR, El Sahly HM, Essink B, et al.
    MeSH term(s) Adult ; COVID-19 ; COVID-19 Vaccines ; Humans ; RNA, Messenger ; SARS-CoV-2 ; Vaccines
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; Vaccines
    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202103160-028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: In adults, the Oxford/AstraZeneca vaccine had 70% efficacy against COVID-19 >14 d after the 2nd dose.

    Chagla, Zain

    Annals of internal medicine

    2021  Volume 174, Issue 3, Page(s) JC29

    Abstract: Source citation: Voysey M, Clemens SA, Madhi SA, et al. ...

    Abstract Source citation: Voysey M, Clemens SA, Madhi SA, et al.
    MeSH term(s) Adult ; Brazil ; COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; South Africa ; United Kingdom ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines ; ChAdOx1 COVID-19 vaccine (B5S3K2V0G8)
    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202103160-029
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  5. Article ; Online: The BNT162b2 (BioNTech/Pfizer) vaccine had 95% efficacy against COVID-19 ≥7 days after the 2nd dose.

    Chagla, Zain

    Annals of internal medicine

    2021  Volume 174, Issue 2, Page(s) JC15

    Abstract: Source citation: Polack FP, Thomas SJ, Kitchin N, et al. ...

    Abstract Source citation: Polack FP, Thomas SJ, Kitchin N, et al.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; RNA, Messenger ; SARS-CoV-2 ; Vaccines
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; Vaccines ; BNT162 vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202102160-015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: In critically ill patients with COVID-19, IL-6 receptor antagonists reduced mortality vs. control at 180 d.

    Fuller, Charlotte / Chagla, Zain

    Annals of internal medicine

    2023  Volume 176, Issue 4, Page(s) JC41

    Abstract: Source citation: Writing Committee for the REMAP-CAP Investigators; Higgins AM, Berry LR, Lorenzi E, et al. ...

    Abstract Source citation: Writing Committee for the REMAP-CAP Investigators; Higgins AM, Berry LR, Lorenzi E, et al.
    MeSH term(s) Humans ; COVID-19 ; Critical Illness ; Receptors, Interleukin-6
    Chemical Substances Receptors, Interleukin-6
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J23-0020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In high-risk outpatients with COVID-19, remdesivir reduced COVID-19-related hospitalization or all-cause death at 28 d.

    Mourad, Omar / Chagla, Zain

    Annals of internal medicine

    2022  Volume 175, Issue 5, Page(s) JC50

    Abstract: Source citation: Gottlieb RL, Vaca CE, Paredes R, et al. ...

    Abstract Source citation: Gottlieb RL, Vaca CE, Paredes R, et al.
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/pharmacology ; Alanine/analogs & derivatives ; Alanine/pharmacology ; COVID-19/drug therapy ; Hospitalization ; Humans ; Outpatients ; SARS-CoV-2
    Chemical Substances remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/J22-0026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers.

    Loeb, Mark / Mertz, Dominik / Chagla, Zain / Conly, John

    Annals of internal medicine

    2023  Volume 176, Issue 7, Page(s) eL230077

    MeSH term(s) Humans ; COVID-19/prevention & control ; N95 Respirators ; Masks ; Health Personnel ; SARS-CoV-2 ; Occupational Exposure/prevention & control
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L23-0077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Monoclonal antibodies as COVID-19 prophylaxis therapy in immunocompromised patient populations.

    Cowan, Juthaporn / Amson, Ashley / Christofides, Anna / Chagla, Zain

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 134, Page(s) 228–238

    Abstract: Objectives: The objective of this review was to examine the latest literature regarding the effectiveness of monoclonal antibodies as COVID-19 prophylaxis therapy for immunocompromised patient populations.: Methods: Literature review of published ... ...

    Abstract Objectives: The objective of this review was to examine the latest literature regarding the effectiveness of monoclonal antibodies as COVID-19 prophylaxis therapy for immunocompromised patient populations.
    Methods: Literature review of published real-world and randomized control trials (RCTs) from 2020 to May 2023.
    Results: COVID-19 is highly transmissible with potentially serious health outcomes, underscoring the need for effective prevention and treatment strategies. Vaccines are highly effective at preventing COVID-19 for the general population; however, efficacy is often impaired in immunocompromised patients given insufficient response to initial exposure and/or memory for secondary exposures. Some individuals may also have contraindications to vaccination. As such, additional protective measures are needed to bolster the immune response in these populations. Monoclonal antibodies have been effective at bolstering immune system responses to COVID-19 among immunocompromised patients; however, they are proving ineffective against the most recent Omicron strains (BA.4 and BA.5).
    Conclusion: Several studies have investigated the efficacy of monoclonal antibodies as pre- and post-prophylaxis for COVID-19. Historical evidence is promising; however, new variants of concern are proving challenging for currently available regimens.
    MeSH term(s) Humans ; Antibodies, Monoclonal/therapeutic use ; COVID-19/prevention & control ; Immunocompromised Host ; Vaccination ; Antibodies, Viral ; Antibodies, Neutralizing
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Viral ; Antibodies, Neutralizing
    Language English
    Publishing date 2023-07-01
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.06.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: In South Africa, a 2-dose Oxford/AZ vaccine did not prevent mild to moderate COVID-19 (cases mainly B.1.351 variant).

    Irfan, Neal / Chagla, Zain

    Annals of internal medicine

    2021  Volume 174, Issue 5, Page(s) JC50

    Abstract: Source citation: Madhi SA, Baillie V, Cutland CL, et al. ...

    Abstract Source citation: Madhi SA, Baillie V, Cutland CL, et al.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; South Africa ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines ; ChAdOx1 COVID-19 vaccine (B5S3K2V0G8)
    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202105180-050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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